Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.

Zhou, Jie; Li, Shantao; Leung, Kevin K; O'Donovan, Brian; Zou, James Y; DeRisi, Joseph L; Wells, James A

Zhou, Jie; Li, Shantao; Leung, Kevin K; O'Donovan, Brian; Zou, James Y; DeRisi, Joseph L; Wells, James A.

Afiliação

Zhou J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Li S; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
O'Donovan B; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Zou JY; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
DeRisi JL; Chan Zuckerberg Biohub, San Francisco, CA 94158.
Wells JA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.

Proc Natl Acad Sci U S A ; 117(41): 25464-25475, 2020 10 13.

Article em En | MEDLINE | ID: mdl-32973096

Assuntos

Caspase 3/metabolismo; Proteoma; Caspase 3/genética; Regulação Enzimológica da Expressão Gênica; Humanos; Biblioteca de Peptídeos; Especificidade por Substrato

Palavras-chave

NGS; human proteome; protease specificity; substrate phage library

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Caspase 3 Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google