Aberrant NSUN2-mediated m<sup>5</sup>C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma.

Sun, Zhen; Xue, Songlei; Zhang, Meiying; Xu, Hui; Hu, Xuming; Chen, Shihao; Liu, Yangyang; Guo, Mingzhou; Cui, Hengmi

Aberrant NSUN2-mediated m⁵C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma.

Sun, Zhen; Xue, Songlei; Zhang, Meiying; Xu, Hui; Hu, Xuming; Chen, Shihao; Liu, Yangyang; Guo, Mingzhou; Cui, Hengmi.

Afiliação

Sun Z; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Xue S; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Zhang M; The General Hospital of the People's Liberation Army (PLAGH), Beijing, China.
Xu H; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Hu X; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Chen S; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Liu Y; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China.
Guo M; The General Hospital of the People's Liberation Army (PLAGH), Beijing, China. mzguo@hotmail.com.
Cui H; Institute of Epigenetics and Epigenomics and College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu, China. hmcui@yzu.edu.cn.

Oncogene ; 39(45): 6906-6919, 2020 11.

Article em En | MEDLINE | ID: mdl-32978516

Assuntos

Carcinoma Hepatocelular/genética; Neoplasias Hepáticas/genética; Metiltransferases/metabolismo; RNA Longo não Codificante/metabolismo; 5-Metilcitosina/metabolismo; Animais; Carcinoma Hepatocelular/patologia; Diferenciação Celular/genética; DNA Helicases/metabolismo; Epigênese Genética; Feminino; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Células Hep G2; Humanos; Fígado/patologia; Neoplasias Hepáticas/patologia; Masculino; Metilação; Metiltransferases/genética; Camundongos; Pessoa de Meia-Idade; Proteínas de Ligação a Poli-ADP-Ribose/metabolismo; RNA Helicases/metabolismo; Proteínas com Motivo de Reconhecimento de RNA/metabolismo; RNA-Seq; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / RNA Longo não Codificante / Neoplasias Hepáticas / Metiltransferases Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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