Photoredox/palladium co-catalyzed propargylic benzylation with internal propargylic carbonates.

Zhou, Zhao-Zhao; Jiao, Rui-Qiang; Yang, Ke; Chen, Xi-Meng; Liang, Yong-Min

Zhou, Zhao-Zhao; Jiao, Rui-Qiang; Yang, Ke; Chen, Xi-Meng; Liang, Yong-Min.

Afiliação

Zhou ZZ; School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, P. R. China. chenxm@lzu.edu.cn and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China. liangym@lzu.edu.cn and Department of Chemistry, Nanchang Normal University, Nanchang,
Jiao RQ; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China. liangym@lzu.edu.cn.
Yang K; Technology Center of China Tabacco Guizhou Industrial Co. Ltd, Guiyang, Guizhou 550000, P. R. China.
Chen XM; School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, P. R. China. chenxm@lzu.edu.cn.
Liang YM; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China. liangym@lzu.edu.cn.

Chem Commun (Camb) ; 56(85): 12957-12960, 2020 Oct 27.

Article em En | MEDLINE | ID: mdl-32986052

RESUMO

Herein, a highly regioselective propargylic benzylation with propargylic carbonates and benzyl 1,4-dihydropyridine derivatives was developed via a photoredox/palladium dual-catalyzed process, which represents a novel catalytic model for non-terminal propargylic functionalization. The reaction showed excellent regioselectivity and functional group compatibility. A radical coupling mechanism between the propargylic radical and benzyl radical was proposed.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido

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