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Terpenes isolated from Polyalthia simiarum and their cytotoxic activities.
Duan, Xiao-Yan; Guo, Kun-Yuan; Lv, Dong-Jin; Mei, Ren-Qiang; Zhang, Mei-De.
Afiliação
  • Duan XY; Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Institute of Chinese Herbal Medicine,
  • Guo KY; Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
  • Lv DJ; Department of Medical Oncology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118, PR China.
  • Mei RQ; Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: meirenqiang@mail.k
  • Zhang MD; Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China. Electronic address: emailtoecho@163.com.
Fitoterapia ; 147: 104734, 2020 Nov.
Article em En | MEDLINE | ID: mdl-33007399
ABSTRACT
Two new C31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC50 value of 22.43 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Polyalthia / Diterpenos Clerodânicos / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Polyalthia / Diterpenos Clerodânicos / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2020 Tipo de documento: Article