Exogenous Clara cell protein 16 attenuates silica particles-induced inflammation in THP-1 macrophages by down-regulating NF-&#954;B and caspase-1 activation.

Cui, Xiuqing; Xu, Ruijun; Zhang, Hai; Peng, Zhe; Feng, Min; Yu, Bo; Wang, Yaqi; Shi, Tingming; Zhou, Yun; Liu, Yuewei

Exogenous Clara cell protein 16 attenuates silica particles-induced inflammation in THP-1 macrophages by down-regulating NF-κB and caspase-1 activation.

Cui, Xiuqing; Xu, Ruijun; Zhang, Hai; Peng, Zhe; Feng, Min; Yu, Bo; Wang, Yaqi; Shi, Tingming; Zhou, Yun; Liu, Yuewei.

Afiliação

Cui X; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Xu R; Department of Epidemiology, School of Public Health, Sun Yat-sen University, China.
Zhang H; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Peng Z; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Feng M; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Yu B; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Wang Y; Department of Epidemiology, School of Public Health, Sun Yat-sen University, China.
Shi T; Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, China.
Zhou Y; State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, China.
Liu Y; School of Public Health, Guangzhou Medical University, China.

J Toxicol Sci ; 45(10): 651-660, 2020.

Article em En | MEDLINE | ID: mdl-33012733

Assuntos

Caspase 1/metabolismo; Expressão Gênica/efeitos dos fármacos; Inflamação/genética; Macrófagos Alveolares/imunologia; Macrófagos/imunologia; NF-kappa B/metabolismo; Dióxido de Silício/toxicidade; Caspase 1/genética; Relação Dose-Resposta a Droga; Regulação para Baixo/efeitos dos fármacos; Poluentes Ambientais/toxicidade; Humanos; NF-kappa B/genética; Tamanho da Partícula; Proteínas Recombinantes/farmacologia; Células THP-1; Uteroglobina/farmacologia

Palavras-chave

Clara cell protein16 (CC16); NF-κB; Silica particles; caspase-1; inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Expressão Gênica / NF-kappa B / Macrófagos Alveolares / Dióxido de Silício / Caspase 1 / Inflamação / Macrófagos Limite: Humans Idioma: En Revista: J Toxicol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Japão

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