Biodegradation kinetics of individual and mixture non-steroidal anti-inflammatory drugs in an agricultural soil receiving alkaline treated biosolids.

ABSTRACT

Land application of biosolids is one potential source of pharmaceuticals and personal care products (PPCPs) into agricultural soils. Degradation is an important natural attenuation pathway that affects the fate and transport of PPCPs in the soil system and biosolids application could alter the process. The present study assessed the effect of individual and mixture compound environments on the biodegradation rate and half-life of three non-steroidal anti-inflammatory drugs (NSAIDs), naproxen (NPX), ibuprofen (IBF), and ketoprofen (KTF), in a loamy sand textured agricultural soil receiving an alkaline treated biosolid (ATB) amendment. A prolonged half-life of the target NSAIDs was determined for sterile soils and shorter half-lives in unsterile soils, indicating the loss of target compounds in all treatments was mainly attributed to biodegradation and followed first-order kinetics. IBF and NPX showed low to moderate persistence in soil and ATB amended soil, with half-lives ranging from 4.9 to 14.8 days, while KTF appeared to be highly persistent with an average half-life of 33 days. The order in which the target NSAIDs disappeared in both soil and ATB amended soil was IBF > NPX > KTF, for both individual and mixture compound treatments. Soils that received the ATB amendment demonstrated inhibited degradation of NPX in all treatments, as well as IBF and KTF in individual compound treatment over the 14-day incubation study. We also observed an inhibition effect from the ATB amendment in sterile soil treatments. In mixture compound treatments, IBF degradation was inhibited in both soil and ATB amended soil. The degradation rate of KTF in mixture compound environment in soil was lower, while the opposite effects were observed in ATB amended soils. For NPX, the degradation was enhanced in mixture compound environment in ATB amended soil, while the same degradation rate of NPX was calculated in soil.