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Pilot study of loss of the p53/p63 target gene PERP at the surgical margin as a potential predictor of local relapse in head and neck squamous cell carcinoma.
Holmes, Brittany J; von Eyben, Rie; Attardi, Laura D; Kong, Christina S; Le, Quynh-Thu; Nathan, Cherie-Ann O.
Afiliação
  • Holmes BJ; Department of Pathology, Stanford University, Stanford, California, USA.
  • von Eyben R; Department of Radiation Oncology, Stanford University, Stanford, California, USA.
  • Attardi LD; Department of Radiation Oncology, Stanford University, Stanford, California, USA.
  • Kong CS; Department of Genetics, Stanford University, Stanford, California, USA.
  • Le QT; Department of Pathology, Stanford University, Stanford, California, USA.
  • Nathan CO; Department of Radiation Oncology, Stanford University, Stanford, California, USA.
Head Neck ; 42(11): 3188-3196, 2020 11.
Article em En | MEDLINE | ID: mdl-33034918
BACKGROUND: PERP (p53 apoptosis effector related to PMP22) localizes to desmosomes and suppresses squamous cell carcinoma development. Loss of PERP leads to worse local control in head and neck squamous cell carcinoma (HNSCC), likely by destabilizing desmosomes. We evaluated PERP loss at HNSCC surgical margins as a predictor of local relapse. METHODS: Combining discovery (n = 17) and validation (n = 31) cohorts, we examined membranous PERP protein expression by immunohistochemistry in surgical mucosal margins with competing risk analysis of the relationship between local relapse and PERP expression. RESULTS: Of the 44 analyzable patients, the 2-year cumulative incidence of local relapse was 44.4% for the PERP-negative group and 16.4% for the PERP-positive group (P = .01). A trend toward worse progression-free survival (P = .09) and overall survival (P = .06) was observed with loss of PERP. CONCLUSIONS: PERP loss at surgical margins is associated with higher risk of local recurrence in HNSCC, warranting further evaluation in a larger prospective study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos