Blood-brain barrier-penetrating siRNA nanomedicine for Alzheimer's disease therapy.

Zhou, Yutong; Zhu, Feiyan; Liu, Yang; Zheng, Meng; Wang, Yibin; Zhang, Dongya; Anraku, Yasutaka; Zou, Yan; Li, Jia; Wu, Haigang; Pang, Xiaobin; Tao, Wei; Shimoni, Olga; Bush, Ashley I; Xue, Xue; Shi, Bingyang

Zhou, Yutong; Zhu, Feiyan; Liu, Yang; Zheng, Meng; Wang, Yibin; Zhang, Dongya; Anraku, Yasutaka; Zou, Yan; Li, Jia; Wu, Haigang; Pang, Xiaobin; Tao, Wei; Shimoni, Olga; Bush, Ashley I; Xue, Xue; Shi, Bingyang.

Afiliação

Zhou Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, China.
Zhu F; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Liu Y; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Zheng M; School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.
Wang Y; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China. bs@henu.edu.cn xuexue@nankai.edu.cn mzheng@henu.edu.cn.
Zhang D; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Anraku Y; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Zou Y; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Li J; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Wu H; Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Pang X; School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.
Tao W; Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
Shimoni O; School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.
Bush AI; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xue X; Institute for Biomedical Materials & Devices (IBMD), School of Mathematical and Physical Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Shi B; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.

Sci Adv ; 6(41)2020 10.

Article em En | MEDLINE | ID: mdl-33036977

Assuntos

Doença de Alzheimer; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Doença de Alzheimer/terapia; Secretases da Proteína Precursora do Amiloide/genética; Secretases da Proteína Precursora do Amiloide/metabolismo; Precursor de Proteína beta-Amiloide/genética; Animais; Ácido Aspártico Endopeptidases/genética; Ácido Aspártico Endopeptidases/metabolismo; Barreira Hematoencefálica/metabolismo; Camundongos; Camundongos Transgênicos; Nanomedicina; RNA Interferente Pequeno/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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