Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation.

Schoger, Eric; Argyriou, Loukas; Zimmermann, Wolfram-Hubertus; Cyganek, Lukas; Zelarayán, Laura Cecilia

Schoger, Eric; Argyriou, Loukas; Zimmermann, Wolfram-Hubertus; Cyganek, Lukas; Zelarayán, Laura Cecilia.

Afiliação

Schoger E; Institute of Pharmacology and Toxicology, University Medical Center Goettingen (UMG), Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany.
Argyriou L; Institute of Human Genetics, University Medical Center Goettingen (UMG), Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany.
Zimmermann WH; Institute of Pharmacology and Toxicology, University Medical Center Goettingen (UMG), Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany.
Cyganek L; Clinic for Cardiology and Pneumology, University Medical Center Goettingen (UMG), Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany.
Zelarayán LC; Institute of Pharmacology and Toxicology, University Medical Center Goettingen (UMG), Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Goettingen, Germany. Electronic address: laura.zelarayan@med.uni-goettingen.de.

Stem Cell Res ; 48: 101944, 2020 10.

Article em En | MEDLINE | ID: mdl-33038615

Assuntos

Células-Tronco Pluripotentes Induzidas; Sistemas CRISPR-Cas/genética; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; Homozigoto; Humanos; Ativação Transcricional

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Stem Cell Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido

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