A cancer-associated, genome protective programme engaging PKCε.
Adv Biol Regul
; 78: 100759, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33039823
ABSTRACT
Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data, but has for the most part not afforded clear mechanistic insights into the control mechanisms at play. Here, we review the roles of PKCε in protecting transformed cells from non-disjunction. In this particular cell cycle context, there is a growing understanding of the pathways involved, affording biomarker and interventional insights and opportunities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genômica
/
Proteína Quinase C-épsilon
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Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Adv Biol Regul
Ano de publicação:
2020
Tipo de documento:
Article