Inhibition of Aurora-A improves insulin resistance by ameliorating islet inflammation and controlling interleukin-6 in a diabetic mouse model.

Meng, Fandong; Sun, Qiangwei; Zhou, Dongmei; Li, Qiang; Han, Jing; Liu, Deshan; Yang, Jing

Meng, Fandong; Sun, Qiangwei; Zhou, Dongmei; Li, Qiang; Han, Jing; Liu, Deshan; Yang, Jing.

Afiliação

Meng F; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University.
Sun Q; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University.
Zhou D; Department of Endocrinology, Wuhan Third Hospital , Wuhan, China.
Li Q; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University.
Han J; Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University.
Liu D; Jiangsu Province Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University.
Yang J; Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University , Jinan, China.

Adipocyte ; 9(1): 609-619, 2020 12.

Article em En | MEDLINE | ID: mdl-33043822

Assuntos

Aurora Quinase A/metabolismo; Diabetes Mellitus Experimental/metabolismo; Resistência à Insulina; Insulina/metabolismo; Interleucina-6/metabolismo; Ilhotas Pancreáticas/metabolismo; Animais; Biomarcadores; Glicemia; Peso Corporal; Diabetes Mellitus Tipo 2/etiologia; Diabetes Mellitus Tipo 2/metabolismo; Modelos Animais de Doenças; Macrófagos/imunologia; Macrófagos/metabolismo; Masculino; Camundongos

Palavras-chave

Aurora-A; IL-6; inflammation; insulin resistance; macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Ilhotas Pancreáticas / Interleucina-6 / Diabetes Mellitus Experimental / Aurora Quinase A / Insulina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Adipocyte Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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