Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging.
Phys Med Biol
; 65(23): 235007, 2020 12 23.
Article
em En
| MEDLINE
| ID: mdl-33049723
ABSTRACT
Magnetic particle imaging (MPI) is a novel and versatile imaging modality developing toward human application. When up-scaling to human size, the sensitivity of the systems naturally drops as the coil sensitivity depends on the bore diameter. Thus, new methods to push the sensitivity limit further have to be investigated to cope for this loss. In this paper a dedicated surface coil for mice is developed, improving the sensitivity in cerebral imaging applications. Similar to magnetic resonance imaging the developed surface coil improves the sensitivity due to the closer vicinity to the region of interest. With the developed surface coil presented in this work, it is possible to image tracer samples containing only 896 pg[Formula see text] and detect even small vessels and anatomical structures within a wild type mouse model. As current sensitivity measures require a tracer system a new method for determining a sensitivity measure without this requirement is presented and verified to enable comparison between MPI receiver systems.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
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Encéfalo
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Imageamento por Ressonância Magnética
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Desenho de Equipamento
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Imagem de Perfusão
Limite:
Animals
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha