Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of <i>Abelmoschus manihot</i> (L.) Medik. on Renal Fibrosis.

Gu, Lifei; Hong, Fang; Fan, Kaikai; Zhao, Lei; Zhang, Chunlei; Yu, Boyang; Chai, Chengzhi

Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis.

Gu, Lifei; Hong, Fang; Fan, Kaikai; Zhao, Lei; Zhang, Chunlei; Yu, Boyang; Chai, Chengzhi.

Afiliação

Gu L; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Hong F; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Fan K; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Zhao L; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Zhang C; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Yu B; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Chai C; Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.

Drug Des Devel Ther ; 14: 4053-4067, 2020.

Article em En | MEDLINE | ID: mdl-33061308

Assuntos

Abelmoschus/química; Medicamentos de Ervas Chinesas/farmacologia; Fibrose/tratamento farmacológico; Extratos Vegetais/farmacologia; Substâncias Protetoras/farmacologia; Insuficiência Renal Crônica/tratamento farmacológico; Animais; Modelos Animais de Doenças; Medicamentos de Ervas Chinesas/química; Medicamentos de Ervas Chinesas/isolamento & purificação; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Fibrose/metabolismo; Fibrose/patologia; Camundongos; Camundongos Endogâmicos ICR; Extratos Vegetais/química; Extratos Vegetais/isolamento & purificação; Substâncias Protetoras/química; Substâncias Protetoras/isolamento & purificação; Insuficiência Renal Crônica/metabolismo; Insuficiência Renal Crônica/patologia

Palavras-chave

5/6 nephrectomy; Abelmoschus manihot (L.) Medik.; active components; network pharmacology; renal fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Medicamentos de Ervas Chinesas / Extratos Vegetais / Substâncias Protetoras / Abelmoschus / Insuficiência Renal Crônica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Drug Des Devel Ther Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2020 Tipo de documento: Article País de publicação: Nova Zelândia

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