Assessing Single-Source Reproducibility of Human Head Hair Peptide Profiling from Different Regions of the Scalp.
Forensic Sci Int Genet
; 50: 102396, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33080487
ABSTRACT
Neither microscopical hair comparisons nor mitochondrial DNA sequencing alone, or together, constitutes a basis for personal identification. Due to these limitations, a complementary technique to compare questioned and known hair shafts was investigated. Recently, scientists from Lawrence Livermore National Laboratory's Forensic Science Center and other collaborators developed a peptide profiling technique, which can infer non-synonymous single nucleotide polymorphisms (SNPs) preserved in hair shaft proteins as single amino acid polymorphisms (SAPs). In this study, peptide profiling was evaluated to determine if it can meet forensic expectations when samples are in limited quantities with the possibility that hair samples collected from different areas of a single donor's scalp (i.e., single source) might not exhibit the same SAP profile. The average dissimilarity, percent differences in SAP profiles within each source, ranged from 0% difference to 29%. This pilot study suggests that more work is needed before peptide profiling of hair can be considered for forensic comparisons.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Couro Cabeludo
/
Cabelo
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Forensic Sci Int Genet
Assunto da revista:
GENETICA
/
JURISPRUDENCIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos