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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
Glasgow, Anum; Glasgow, Jeff; Limonta, Daniel; Solomon, Paige; Lui, Irene; Zhang, Yang; Nix, Matthew A; Rettko, Nicholas J; Zha, Shoshana; Yamin, Rachel; Kao, Kevin; Rosenberg, Oren S; Ravetch, Jeffrey V; Wiita, Arun P; Leung, Kevin K; Lim, Shion A; Zhou, Xin X; Hobman, Tom C; Kortemme, Tanja; Wells, James A.
Afiliação
  • Glasgow A; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
  • Glasgow J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Limonta D; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
  • Solomon P; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
  • Lui I; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Zhang Y; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Nix MA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
  • Rettko NJ; Department of Laboratory Medicine, University of California, San Francisco, CA 94143.
  • Zha S; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Yamin R; Department of Medicine, University of California, San Francisco, CA 94143.
  • Kao K; Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065.
  • Rosenberg OS; Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065.
  • Ravetch JV; Department of Medicine, University of California, San Francisco, CA 94143.
  • Wiita AP; Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065.
  • Leung KK; Department of Laboratory Medicine, University of California, San Francisco, CA 94143.
  • Lim SA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Zhou XX; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Hobman TC; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
  • Kortemme T; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
  • Wells JA; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Proc Natl Acad Sci U S A ; 117(45): 28046-28055, 2020 11 10.
Article em En | MEDLINE | ID: mdl-33093202
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Desenho de Fármacos / Engenharia de Proteínas / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Desenho de Fármacos / Engenharia de Proteínas / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos