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Lymph Node Stromal Cells: Mapmakers of T Cell Immunity.
Harlé, Guillaume; Kowalski, Camille; Garnier, Laure; Hugues, Stéphanie.
Afiliação
  • Harlé G; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1206 Geneva, Switzerland.
  • Kowalski C; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1206 Geneva, Switzerland.
  • Garnier L; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1206 Geneva, Switzerland.
  • Hugues S; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1206 Geneva, Switzerland.
Int J Mol Sci ; 21(20)2020 Oct 21.
Article em En | MEDLINE | ID: mdl-33096748
Stromal cells (SCs) are strategically positioned in both lymphoid and nonlymphoid organs to provide a scaffold and orchestrate immunity by modulating immune cell maturation, migration and activation. Recent characterizations of SCs have expanded our understanding of their heterogeneity and suggested a functional specialization of distinct SC subsets, further modulated by the microenvironment. Lymph node SCs (LNSCs) have been shown to be particularly important in maintaining immune homeostasis and T cell tolerance. Under inflammation situations, such as viral infections or tumor development, SCs undergo profound changes in their numbers and phenotype and play important roles in contributing to either the activation or the control of T cell immunity. In this review, we highlight the role of SCs located in LNs in shaping peripheral T cell responses in different immune contexts, such as autoimmunity, viral and cancer immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Viroses / Linfócitos T / Células Estromais / Linfonodos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Viroses / Linfócitos T / Células Estromais / Linfonodos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Suíça