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Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder.
Jia, Cuicui; Ou, Yangpan; Chen, Yunhui; Li, Ping; Lv, Dan; Yang, Ru; Zhong, Zhaoxi; Sun, Lei; Wang, Yuhua; Zhang, Guangfeng; Guo, Hong; Sun, Zhenghai; Wang, Wei; Wang, Yefu; Wang, Xiaoping; Guo, Wenbin.
Afiliação
  • Jia C; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Ou Y; National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Chen Y; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Li P; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Lv D; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Yang R; Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Zhong Z; Henan Key Lab of Biological Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
  • Sun L; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Wang Y; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Zhang G; Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
  • Guo H; Department of Radiology, The First Hospital of Qiqihar, Qiqihar, China.
  • Sun Z; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Wang W; Department of Library, Qiqihar Medical University, Qiqihar, China.
  • Wang Y; Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
  • Wang X; National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Guo W; National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Psychiatry ; 11: 559729, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33101081
ABSTRACT

Objective:

Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD.

Methods:

Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data.

Results:

Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs.

Conclusions:

Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Front Psychiatry Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Front Psychiatry Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China