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Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3ß Inhibitors with Improved Metabolic Stability.
Andreev, Stanislav; Pantsar, Tatu; El-Gokha, Ahmed; Ansideri, Francesco; Kudolo, Mark; Anton, Débora Bublitz; Sita, Giulia; Romasco, Jenny; Geibel, Christian; Lämmerhofer, Michael; Goettert, Márcia Ines; Tarozzi, Andrea; Laufer, Stefan A; Koch, Pierre.
Afiliação
  • Andreev S; Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Pantsar T; Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • El-Gokha A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
  • Ansideri F; Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Kudolo M; Chemistry Department, Faculty of Science, Menoufia University, Gamal Abdel-Nasser Street, Shebin El-Kom 32511, Egypt.
  • Anton DB; Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Sita G; Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Romasco J; Cell Culture Laboratory, Postgraduate Program in Biotechnology, University of Vale do Taquari (Univates), Lajeado 95914-014, Brazil.
  • Geibel C; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy.
  • Lämmerhofer M; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso D'Augusto, 237, 47921 Rimini, Italy.
  • Goettert MI; Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Tarozzi A; Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Laufer SA; Cell Culture Laboratory, Postgraduate Program in Biotechnology, University of Vale do Taquari (Univates), Lajeado 95914-014, Brazil.
  • Koch P; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso D'Augusto, 237, 47921 Rimini, Italy.
Int J Mol Sci ; 21(21)2020 Oct 22.
Article em En | MEDLINE | ID: mdl-33105671
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Glicogênio Sintase Quinase 3 beta Limite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Glicogênio Sintase Quinase 3 beta Limite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça