Xanthones from <i>Securidaca inappendiculata</i> antagonized the antirheumatic effects of methotrexate <i>in vivo</i> by promoting its secretion into urine.

Wang, Dan-Dan; Li, Yan; Wu, Yi-Jin; Wu, Yi-Lai; Han, Jun; Olatunji, Opeyemi Joshua; Wang, Li; Zuo, Jian

Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.

Wang, Dan-Dan; Li, Yan; Wu, Yi-Jin; Wu, Yi-Lai; Han, Jun; Olatunji, Opeyemi Joshua; Wang, Li; Zuo, Jian.

Afiliação

Wang DD; Department of Traditional Chinese Medicine, The First Aï¬liated Hospital of Wannan Medical College (Yijishan Hospital) , Wuhu, China.
Li Y; Department of Traditional Chinese Medicine, The First Aï¬liated Hospital of Wannan Medical College (Yijishan Hospital) , Wuhu, China.
Wu YJ; Department of Pharmacy, The Second Aï¬liated Hospital of Wannan Medical College , Wuhu, Anhui, China.
Wu YL; Department of Traditional Chinese Medicine, The First Aï¬liated Hospital of Wannan Medical College (Yijishan Hospital) , Wuhu, China.
Han J; Drug Research and Development Center, School of Pharmacy, Wannan Medical College , Wuhu, Anhui, China.
Olatunji OJ; Faculty of Traditional Thai Medicine, Prince of Songkla University , Hat Yai, Thailand.
Wang L; Department of Pharmacy, Wuhu Medicine and Health School , Wuhu, Anhui, China.
Zuo J; Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College , Wuhu, Anhui, China.

Expert Opin Drug Metab Toxicol ; 17(2): 241-250, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33107357

Assuntos

Antirreumáticos/farmacologia; Artrite Experimental/tratamento farmacológico; Metotrexato/farmacologia; Securidaca/química; Xantonas/farmacologia; Animais; Antirreumáticos/farmacocinética; Cromatografia Líquida de Alta Pressão; Cromatografia Líquida; Células HEK293; Interações Ervas-Drogas; Humanos; Masculino; Espectrometria de Massas; Metotrexato/farmacocinética; Ratos; Ratos Sprague-Dawley; Xantonas/isolamento & purificação

Palavras-chave

Pharmacokinetics; drug transporter; drug-drug interaction; organic anion transporter 3 (OAT3); rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Metotrexato / Antirreumáticos / Securidaca / Xantonas Limite: Animals / Humans / Male Idioma: En Revista: Expert Opin Drug Metab Toxicol Assunto da revista: METABOLISMO / TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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