The Association Between Obesity and Risk of Acute Kidney Injury After Cardiac Surgery.
Front Endocrinol (Lausanne)
; 11: 534294, 2020.
Article
em En
| MEDLINE
| ID: mdl-33123083
ABSTRACT
Objective:
To determine the relationship between obesity and the risk of AKI after cardiac surgery (CS-AKI) in a cohort study.Methods:
A total of 1,601 patients undergoing cardiac surgery were collected and their incidence of CS-AKI was recorded. They were divided into underweight, normal weight, overweight, and obese groups. Logistic regression was used to estimate the association between BMI (body mass index) and CS-AKI risk. Then, a meta-analysis of published cohort studies was conducted to confirm this result using PubMed and Embase databases.Results:
A significant association was observed in this independent cohort after adjusting age, gender, hypertension and New York Heart Association classification (NYHA) class. Compared with normal BMI group (18.5 ≤ BMI < 24.0), the individuals with aberrant BMI level had an increased AKI risk (OR 1.68, 95% CI 1.01-2.78) for BMI < 18.5 group and (OR 1.43, 95% CI 0.96-2.15) for BMI ≥ 28.0. Interestingly, the U-shape curve showed the CS-AKI risk reduced with the increasing of BMI when BMI ≤ 24.0. As BMI increases with BMI > 24.0, the risk of developing CS-AKI increased significantly. In the confirmed meta-analysis, compared with normal weight, overweight group with cardiac surgery had higher AKI risk (OR 1.28, 95% CI 1.16-1.41, Pheterogeneity = 0.49). The similar association was found in obesity subgroup (OR 1.79, 95% CI 1.57-2.03, Pheterogeneity = 0.42).Conclusion:
In conclusion, the results suggested that abnormal BMI was a risk factor for CS-AKI independently.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Injúria Renal Aguda
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Procedimentos Cirúrgicos Cardíacos
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China