Lifetime Care of Duchenne Muscular Dystrophy.
Sleep Med Clin
; 15(4): 485-495, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33131659
ABSTRACT
Individuals with Duchenne muscular dystrophy (DMD) have evolving sleep and respiratory pathophysiology over their lifetimes. Across the lifespan of DMD, various sleep-related breathing disorders (SRBD) have been described, including obstructive sleep apnea, central sleep apnea, and nocturnal hypoventilation. In addition to SRBD, individuals with DMD can be affected by insomnia, chronic pain and other factors interfering with sleep quality, and daytime somnolence. The natural progression of DMD pathophysiology has changed with the introduction of therapies for downstream pathologic pathways and will continue to evolve with the development of therapies that target function and expression of dystrophin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
/
Distrofia Muscular de Duchenne
Limite:
Humans
Idioma:
En
Revista:
Sleep Med Clin
Ano de publicação:
2020
Tipo de documento:
Article