Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals.
Mol Genet Genomic Med
; 8(12): e1541, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33135867
ABSTRACT
BACKGROUND:
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case-control study to evaluate the possible association between rs619586 and rs3200401 SNPs in MALAT and GC risk.METHODS:
Samples from 458 patients with GC and 381 controls were genotyped using the TaqMan genotyping assay.RESULTS:
In stratified analyses, we observed that rs3200401 CT in the codominant model and CT+TT in the dominant model were associated with increased GC risk in male patients (CT odds ratio [OR] = 1.81, 95% confidence interval [CI] = 1.09-3.01, p = 0.022; CT+TT OR = 1.74, 95% CI = 1.07-2.83, p = 0.026), and the differentiated (CT OR =1.79, 95% CI = 1.18-2.73, p = 0.007; CT+TT OR = 1.76, 95% CI = 1.17-2.64, p = 0.007), and intestinal (CT OR = 1.67, 95% CI = 1.11-2.49, p = 0.013; CT+TT OR = 1.68, 95% CI = 1.14-2.47, p = 0.009) GC subgroups.CONCLUSION:
MALAT1 rs3200401 increases GC susceptibility and might affect GC development. Further studies are needed to validate our results in large populations and different ethnic groups.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Polimorfismo de Nucleotídeo Único
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RNA Longo não Codificante
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
/
Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Mol Genet Genomic Med
Ano de publicação:
2020
Tipo de documento:
Article