Isolation and characterisation of N-benzyl tadalafil as a novel adulterant in a coffee-based dietary supplement.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
; 37(12): 2033-2039, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33136528
ABSTRACT
A new tadalafil analogue was detected via high-performance liquid chromatography (HPLC)-diode array detection (DAD) during routine screening of health foods suspected of adulteration with erectile dysfunction drugs. The UV absorption spectrum of the unknown was almost identical to that of tadalafil. The analogue was puriï¬ed by preparative HPLC and structural elucidation carried out by mass spectrometric and NMR spectroscopic experiments. The spectral data revealed that this tadalafil analogue bears a benzyl group instead of the methyl group. The isolated compound was identified as N-benzyl tadalafil. Considering the risk it poses to public health, this new PDE-5 analogues for ED should be included on the inspection list for illegal products.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contaminação de Alimentos
/
Contaminação de Medicamentos
/
Café
/
Suplementos Nutricionais
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Inibidores da Fosfodiesterase 5
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Tadalafila
Limite:
Humans
Idioma:
En
Revista:
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2020
Tipo de documento:
Article