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Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
Guan, Yidi; Jiang, Shilong; Ye, Wenling; Ren, Xingcong; Wang, Xinluan; Zhang, Yi; Yin, Mingzhu; Wang, Kuansong; Tao, Yongguang; Yang, JinMing; Cao, Dongsheng; Cheng, Yan.
Afiliação
  • Guan Y; Department of Pharmacy, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.
  • Jiang S; Department of Pharmacy, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.
  • Ye W; Xiangya School of Pharmaceutical Sciences, Central South University, 410008, Changsha, Hunan, China.
  • Ren X; Department of Cancer Biology and Toxicology, Department of Pharmacology, College of Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.
  • Wang X; Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518057, Shenzhen, China.
  • Zhang Y; Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
  • Yin M; Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
  • Wang K; Department of Pathology, Xiangya Hospital, Central South University, 410078, Changsha, China.
  • Tao Y; Cancer Research Institute, School of Basic Medicine, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Central South University, 410008, Changsha, Hunan, China.
  • Yang J; Department of Cancer Biology and Toxicology, Department of Pharmacology, College of Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.
  • Cao D; Xiangya School of Pharmaceutical Sciences, Central South University, 410008, Changsha, Hunan, China. oriental-cds@163.com.
  • Cheng Y; Department of Pharmacy, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China. yancheng@csu.edu.cn.
Cell Death Dis ; 11(11): 948, 2020 11 03.
Article em En | MEDLINE | ID: mdl-33144562
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Mitoxantrona / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Quinase do Fator 2 de Elongação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Mitoxantrona / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Quinase do Fator 2 de Elongação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido