Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study.
Alcohol Alcohol
; 56(1): 42-46, 2021 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-33150930
ABSTRACT
AIMS:
We conducted a cross-sectional survey to estimate the prevalence and clinical manifestation of disulfiram ethanol reaction (DER) and isopropanol toxicity (IT) in patients with alcohol use disorders, on disulfiram. Alcohol-based hand rub contains either ethanol or isopropanol or both. COVID-19 pandemic has led to wide scale usage of sanitizers. Patients with alcohol use disorders, on disulfiram, might experience disulfiram ethanol like reactions with alcohol-based sanitizers.METHODS:
We telephonically contacted 339 patients, prescribed disulfiram between January 2014 and March 2020. The assessment pertained to the last 3 months (i.e. third week of March to third week of June 2020).RESULT:
The sample consisted of middle-aged men with a mean 16 years of alcohol dependence. Among the 82 (24%) patients adherent to disulfiram, 42 (12.3%) were using alcohol-based hand rubs. Out of these, a total of eight patients (19%; 95% CI 9-33) had features suggestive of DER; four of whom also had features indicative of IT. Five patients (62.5%) had mild and self-limiting symptoms. Severe systemic reactions were experienced by three (37.5%). Severe reactions were observed with exposure to sanitizers in greater amounts, on moist skin or through inhalation.CONCLUSION:
Patients on disulfiram should be advised to use alternate methods of hand hygiene.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dissulfiram
/
Dissuasores de Álcool
/
Etanol
/
Alcoolismo
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Higienizadores de Mão
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Alcohol Alcohol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia