Impaired intestinal barrier function in type 2 diabetic patients measured by serum LPS, Zonulin, and IFABP.
J Diabetes Complications
; 35(2): 107766, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33168395
ABSTRACT
INTRODUCTION:
The epithelial tight junctions of intestine were impaired in murine model of type 2 diabetes mellitus (T2DM). The aim of this work was to investigate the alteration of intestinal barrier in T2DM patients.METHODS:
90 patients with T2DM and 28 healthy controls were recruited. Serum lipopolysaccharide (LPS), Zonulin, and intestinal fatty acid binding protein (IFABP) were measured by ELISA, based on which a derived permeability risk score (PRS) was calculated. Subgroup analyses were conducted based on the glycemic control (HbA1câ¯<â¯7%, or HbA1câ¯≥â¯7%), the amount of chronic diabetic complications, and the use of aspirin at the time.RESULTS:
Serum LPS, Zonulin, and IFABP, and PRS of T2DM group were significantly higher than those of the control group (pâ¯<â¯0.05 for all). Serum LPS and PRS was higher in T2DM patients with poor glycemic control (both pâ¯<â¯0.05). Patients with more chronic complications of diabetes had higher serum LPS and IFABP, and PRS (all pâ¯<â¯0.05). No differences were found in these serum markers between T2DM patients being treated with aspirin or not.CONCLUSIONS:
Intestinal barrier function was impaired in T2DM patients. Poor glycemic control and more chronic complications of diabetes were associated with worse intestinal barrier function. Treatment with aspirin did not aggravate the impairment of intestinal barrier in T2DM patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Lipopolissacarídeos
/
Diabetes Mellitus Tipo 2
/
Proteínas de Ligação a Ácido Graxo
/
Mucosa Intestinal
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Diabetes Complications
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article