Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults.

Shoemaker, L N; Wilson, L C; Lucas, S J E; Machado, L; Walker, R J; Cotter, J D

Shoemaker, L N; Wilson, L C; Lucas, S J E; Machado, L; Walker, R J; Cotter, J D.

Afiliação

Shoemaker LN; School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand.
Wilson LC; Department of Medicine, Otago Medical School - Dunedin Campus, University of Otago, Dunedin, New Zealand.
Lucas SJE; Department of Physiology, University of Otago, Dunedin, New Zealand.
Machado L; School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Walker RJ; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Cotter JD; Department of Psychology, University of Otago, Dunedin, New Zealand.

J Physiol ; 599(4): 1097-1113, 2021 02.

Article em En | MEDLINE | ID: mdl-33185896

Assuntos

Circulação Cerebrovascular; Indometacina; Idoso; Cognição; Humanos; Hipocapnia; Perfusão; Adulto Jovem

Palavras-chave

ageing; cerebral blood flow; cognition; hypercapnia; indomethacin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Circulação Cerebrovascular / Indometacina Tipo de estudo: Clinical_trials Limite: Adult / Aged / Humans Idioma: En Revista: J Physiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Nova Zelândia País de publicação: Reino Unido

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