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Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization.
Xiong, Yao; Wang, Yan; Ma, Ling; Zhang, Ying; Qu, Xinlan; Huang, Lei; Wen, Xue; Liu, Huimin; Zhang, Ming; Zhang, Yuanzhen.
Afiliação
  • Xiong Y; Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Wang Y; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.
  • Ma L; Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhang Y; Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Qu X; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.
  • Huang L; Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Wen X; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.
  • Liu H; Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhang M; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.
  • Zhang Y; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China.
J Cell Mol Med ; 2020 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-33201593
ABSTRACT
Studies have reported that non-receptive endometrium or abnormal decidualization was closely related to recurrent implantation failure (RIF). MLL1 is a histone H3 lysine 4 trimethylation (H3K4me3) transferase that regulates the transcriptional activation of target genes. The role of MLL1 has been underexplored during decidualization. In our research, we found the expression of MLL1 was closely related to endometrial receptivity, and it was responsible to hormone stimulation. Inhibiting the function of MLL1 by MM102 reduced the transformation of HESCs. Furthermore, down-regulation of MLL1 by siRNA transfection significantly decreased PGR and its target genes expression. MLL1 act as a co-activator of ERα, and both of them were recruited to PGR regulatory regions, thus promote PGR transcription. Our study showed that MLL1 plays a key role in promoting progesterone signalling transmission.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Assunto da revista: Biologia Molecular Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Assunto da revista: Biologia Molecular Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China