MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-&#945;/TGF-ß1/IL-10 Signaling via Targeting IRF1/SP1.

Chen, Yung-Che; Lee, Chiu Ping; Hsiao, Chang-Chun; Hsu, Po-Yuan; Wang, Ting-Ya; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Chang, Yu-Ping; Lin, Meng-Chih

MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-ß1/IL-10 Signaling via Targeting IRF1/SP1.

Chen, Yung-Che; Lee, Chiu Ping; Hsiao, Chang-Chun; Hsu, Po-Yuan; Wang, Ting-Ya; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Chang, Yu-Ping; Lin, Meng-Chih.

Afiliação

Chen YC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lee CP; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Hsiao CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Hsu PY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Wang TY; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Wu CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chao TY; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Leung SY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chang YP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lin MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Int J Mol Sci ; 21(22)2020 Nov 14.

Article em En | MEDLINE | ID: mdl-33202583

Assuntos

Regulação para Baixo; Fator Regulador 1 de Interferon/metabolismo; Interleucina-10/metabolismo; MicroRNAs/biossíntese; Mycobacterium tuberculosis/metabolismo; Fagocitose; Transdução de Sinais; Fator de Transcrição Sp1/metabolismo; Receptor 4 Toll-Like/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Tuberculose Pulmonar/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Feminino; Humanos; Fator Regulador 1 de Interferon/genética; Interleucina-10/genética; Masculino; MicroRNAs/genética; Fator de Transcrição Sp1/genética; Células THP-1; Receptor 4 Toll-Like/genética; Fator de Crescimento Transformador beta1/genética; Tuberculose Pulmonar/genética; Fator de Necrose Tumoral alfa/genética

Palavras-chave

IL10; TLR4; active pulmonary TB disease; latent TB infection; miR-23a-3p

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fagocitose / Tuberculose Pulmonar / Transdução de Sinais / Regulação para Baixo / Fator de Transcrição Sp1 / Fator de Necrose Tumoral alfa / Interleucina-10 / MicroRNAs / Fator Regulador 1 de Interferon / Receptor 4 Toll-Like Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google