Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-&#954;B pathways in the striatum.

Yang, Xiong; Chu, Shi-Feng; Wang, Zhen-Zhen; Li, Fang-Fang; Yuan, Yu-He; Chen, Nai-Hong

Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways in the striatum.

Yang, Xiong; Chu, Shi-Feng; Wang, Zhen-Zhen; Li, Fang-Fang; Yuan, Yu-He; Chen, Nai-Hong.

Afiliação

Yang X; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Chu SF; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wang ZZ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Li FF; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yuan YH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Chen NH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. chennh@imm.ac.cn.

Acta Pharmacol Sin ; 42(9): 1409-1421, 2021 Sep.

Article em En | MEDLINE | ID: mdl-33214696

Assuntos

Corpo Estriado/metabolismo; Ginsenosídeos/farmacologia; Doença de Huntington/metabolismo; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Fármacos Neuroprotetores/farmacologia; Animais; Apoptose; Corpo Estriado/patologia; Corpo Estriado/ultraestrutura; Doença de Huntington/induzido quimicamente; Doença de Huntington/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microglia/efeitos dos fármacos; Microglia/metabolismo; Neurônios/efeitos dos fármacos; Nitrocompostos; Propionatos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

3-nitropropionic acid; Huntington's disease; MAPKs; NF-κB; ginsenoside Rg1; neuroprotective effects; striatum

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Doença de Huntington / Fármacos Neuroprotetores / Corpo Estriado / Quinases de Proteína Quinase Ativadas por Mitógeno / Ginsenosídeos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google