Front-line daratumumab-VTd versus standard-of-care in ASCT-eligible multiple myeloma: matching-adjusted indirect comparison.
Immunotherapy
; 13(2): 143-154, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33228440
ABSTRACT
Aim:
To compare daratumumab plus standard-of-care (SoC; bortezomib/thalidomide/dexamethasone [VTd]) and VTd alone with other SoC for transplant-eligible newly diagnosed multiple myeloma. Patients &methods:
We conducted an unanchored matching-adjusted indirect comparison of progression-free and overall survival (PFS/OS) with D-VTd/VTd versus bortezomib/lenalidomide/dexamethasone (VRd), bortezomib/cyclophosphamide/dexamethasone (VCd) and bortezomib/dexamethasone (Vd).Results:
After matching adjustment, significant improvements in PFS were estimated for D-VTd versus VRd (hazard ratio [HR] 0.47 [95% CI 0.33-0.69]), VCd (HR 0.35 [95% CI 0.21-0.58]) and Vd (HR 0.42 [95% CI 0.28-0.63]). OS was significantly longer with D-VTd versus VRd (HR 0.31 [95% CI 0.16-0.57]), VCd (HR 0.35 [95% CI 0.14-0.86]) and Vd (HR 0.38 [95% CI 0.18-0.77]). No significant PFS/OS differences were seen for VTd versus other SoC.Conclusion:
This analysis supports front-line daratumumab for transplant-eligible newly diagnosed multiple myeloma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Anticorpos Monoclonais
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Mieloma Múltiplo
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
França