Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination.
Trends Biochem Sci
; 46(3): 184-199, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33250286
ABSTRACT
Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B cells that diversifies the effector component of antibody responses. CSR is initiated by the activity of the B cell-specific enzyme activation-induced cytidine deaminase (AID), which leads to the formation of programmed DNA double-strand breaks (DSBs) at the Ig heavy chain (Igh) locus. Mature B cells use a multilayered and complex regulatory framework to ensure that AID-induced DNA breaks are channeled into productive repair reactions leading to CSR, and to avoid aberrant repair events causing lymphomagenic chromosomal translocations. Here, we review the DNA repair pathways acting on AID-induced DSBs and their functional interplay, with a particular focus on the latest developments in their molecular composition and mechanistic regulation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Switching de Imunoglobulina
/
Quebras de DNA de Cadeia Dupla
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha