Electrospun formulation of acyclovir/cyclodextrin nanofibers for fast-dissolving antiviral drug delivery.
Mater Sci Eng C Mater Biol Appl
; 118: 111514, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33255070
ABSTRACT
Acyclovir is an effective antiviral drug which suffers from limited water solubility and low bioavailability. However, it is possible to eliminate these limitations by forming inclusion complexes with cyclodextrins. In this study, we have reported the electrospinning of polymer-free and free-standing acyclovir/cyclodextrin nanofibers for the first time. This is a promising approach for developing a fast-dissolving delivery system of an antiviral drug molecule. Here, hydroxypropyl-beta-cyclodextrin (HP-ßCD) was used as both complexation agent and electrospinning matrix. The acyclovir/HP-ßCD system was prepared by incorporating ~7% (w/w) of acyclovir into the highly concentrated aqueous solution of HP-ßCD (180%, w/v). The control sample of acyclovir/polyvinylpyrrolidone (PVP) nanofiber were also generated using ethanol/water (3/1, v/v) solvent system and the same initial acyclovir (7%, w/w) content. Due to the inclusion complexation, acyclovir/HP-ßCD nanofibers provided better encapsulation and so loading efficiency. The loading efficiency of acyclovir/HP-ßCD nanofibers was determined as ~98%, while it was ~66% for acyclovir/PVP nanofibers. It was found that acyclovir/HP-ßCD nanofibers contained some crystalline form of acyclovir. Even so, it showed faster dissolving/release and faster disintegration profiles compared to acyclovir/PVP nanofibers which had higher amount of crystalline acyclovir. The inclusion complexation property and high water solubility of HP-ßCD (> 2000 mg/mL) ensured the fast-dissolving property of acyclovir/HP-ßCD nanofibers. Briefly, acyclovir/HP-ßCD nanofibers are quite promising alternative to the polymeric based system for the purpose of fast-dissolving oral drug delivery. The enhanced physicochemical properties of drug molecules and the use of water during whole process can make drug/cyclodextrin nanofibers a favorable dosage formulation for the desired treatments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclodextrinas
/
Nanofibras
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Ano de publicação:
2021
Tipo de documento:
Article