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Association of apolipoprotein C3 with insulin resistance and coronary artery calcium in patients with type 1 diabetes.
Buckner, Teresa; Shao, Baohai; Eckel, Robert H; Heinecke, Jay W; Bornfeldt, Karin E; Snell-Bergeon, Janet.
Afiliação
  • Buckner T; Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: teresa.buckner@cuanschutz.edu.
  • Shao B; Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, WA, USA.
  • Eckel RH; Division of Endocrinology, Metabolism and Diabetes, and Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Heinecke JW; Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, WA, USA.
  • Bornfeldt KE; Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington Medicine Diabetes Institute, Uni
  • Snell-Bergeon J; Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J Clin Lipidol ; 15(1): 235-242, 2021.
Article em En | MEDLINE | ID: mdl-33257283
BACKGROUND: Apolipoprotein C3 (APOC3) is a risk factor for incident coronary artery disease in people with type 1 diabetes (T1D). The pathways that link elevated APOC3 levels to an increased risk of incident cardiovascular disease in people with T1D are not understood. OBJECTIVE: To explore potential mechanisms, we investigated the association of APOC3 with insulin resistance and coronary artery calcium (CAC). METHODS: In a random subcohort of participants with T1D from Coronary Artery Calcification in Type 1 Diabetes (n = 134), serum APOC3, high-density lipoprotein (HDL)-associated APOC3, and retinol binding protein 4 (RBP4; a potential marker of insulin resistance) were measured by targeted mass spectrometry. We used linear regression to evaluate associations of serum APOC3 and HDL-APOC3 with APOB, non-HDL cholesterol, serum- and HDL-associated RBP4, and estimated insulin sensitivity and logistic regression to evaluate association with presence of CAC, adjusted for age, sex, and diabetes duration. RESULTS: Serum APOC3 correlated positively with APOB and non-HDL cholesterol and was associated with increased odds of CAC (odds ratio: 1.68, P = .024). Estimated insulin sensitivity was not associated with serum- or HDL-RBP4 but was negatively associated with serum APOC3 in men (ß estimate: -0.318, P = .0040) and decreased odds of CAC (odds ratio: 0.434, P = .0023). CONCLUSIONS: Serum APOC3 associates with increased insulin resistance and CAC in T1D.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos