A TLR7/8 Agonist-Including DOEPC-Based Cationic Liposome Formulation Mediates Its Adjuvanticity Through the Sustained Recruitment of Highly Activated Monocytes in a Type I IFN-Independent but NF-&#954;B-Dependent Manner.

Auderset, Floriane; Belnoue, Elodie; Mastelic-Gavillet, Beatris; Lambert, Paul-Henri; Siegrist, Claire-Anne

A TLR7/8 Agonist-Including DOEPC-Based Cationic Liposome Formulation Mediates Its Adjuvanticity Through the Sustained Recruitment of Highly Activated Monocytes in a Type I IFN-Independent but NF-κB-Dependent Manner.

Auderset, Floriane; Belnoue, Elodie; Mastelic-Gavillet, Beatris; Lambert, Paul-Henri; Siegrist, Claire-Anne.

Afiliação

Auderset F; World Health Organization Collaborating Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland.
Belnoue E; World Health Organization Collaborating Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland.
Mastelic-Gavillet B; World Health Organization Collaborating Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland.
Lambert PH; World Health Organization Collaborating Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland.
Siegrist CA; World Health Organization Collaborating Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland.

Front Immunol ; 11: 580974, 2020.

Article em En | MEDLINE | ID: mdl-33262759

Assuntos

Adjuvantes Imunológicos/administração & dosagem; Glicoproteínas de Membrana/agonistas; Monócitos/imunologia; Receptor 7 Toll-Like/agonistas; Receptor 8 Toll-Like/agonistas; Animais; Linfócitos B/imunologia; Células Dendríticas/imunologia; Composição de Medicamentos; Centro Germinativo/imunologia; Compostos Heterocíclicos com 3 Anéis/administração & dosagem; Imunidade Inata; Interferon Tipo I/imunologia; Ligantes; Lipossomos/administração & dosagem; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; NF-kappa B/deficiência; NF-kappa B/genética; NF-kappa B/imunologia; Fosfatidilcolinas/administração & dosagem; Receptor de Interferon alfa e beta/deficiência; Receptor de Interferon alfa e beta/genética; Receptor de Interferon alfa e beta/imunologia; Transdução de Sinais/imunologia; Ácidos Esteáricos/administração & dosagem; Células Th1/imunologia

Palavras-chave

TLR7/8 agonist; adjuvants for vaccine; follicular T helper cells; germinal centers; liposome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Monócitos / Adjuvantes Imunológicos / Receptor 7 Toll-Like / Receptor 8 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Suíça

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