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A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.
Nachbagauer, Raffael; Feser, Jodi; Naficy, Abdollah; Bernstein, David I; Guptill, Jeffrey; Walter, Emmanuel B; Berlanda-Scorza, Franceso; Stadlbauer, Daniel; Wilson, Patrick C; Aydillo, Teresa; Behzadi, Mohammad Amin; Bhavsar, Disha; Bliss, Carly; Capuano, Christina; Carreño, Juan Manuel; Chromikova, Veronika; Claeys, Carine; Coughlan, Lynda; Freyn, Alec W; Gast, Christopher; Javier, Andres; Jiang, Kaijun; Mariottini, Chiara; McMahon, Meagan; McNeal, Monica; Solórzano, Alicia; Strohmeier, Shirin; Sun, Weina; Van der Wielen, Marie; Innis, Bruce L; García-Sastre, Adolfo; Palese, Peter; Krammer, Florian.
Afiliação
  • Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Feser J; Moderna, Cambridge, MA, USA.
  • Naficy A; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Bernstein DI; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Guptill J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Walter EB; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Berlanda-Scorza F; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Stadlbauer D; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Wilson PC; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
  • Aydillo T; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Behzadi MA; GSK, Siena, Italy.
  • Bhavsar D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bliss C; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Capuano C; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Chromikova V; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Claeys C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Coughlan L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Freyn AW; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gast C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Javier A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jiang K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Mariottini C; GSK, Wavre, Belgium.
  • McMahon M; Spmt-Arista Asbl, Brussels, Belgium.
  • McNeal M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Solórzano A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Strohmeier S; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sun W; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Van der Wielen M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Innis BL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Krammer F; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nat Med ; 27(1): 106-114, 2021 01.
Article em En | MEDLINE | ID: mdl-33288923
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Glicoproteínas de Hemaglutininação de Vírus da Influenza Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Glicoproteínas de Hemaglutininação de Vírus da Influenza Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos