Radiologically isolated syndrome: targeting miRNAs as prognostic biomarkers.
Epigenomics
; 12(23): 2065-2076, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33290101
ABSTRACT
Aim:
Some clinical and biological characteristics have been described as prognostic factors for clinical conversion into clinically definite multiple sclerosis in radiologically isolated syndrome (RIS) population. The aim of this study was to assess signatures of circulating miRNAs in those patients according to their conversion status after 5 years of follow-up. Patients &methods:
OpenArray plates assessing 216 miRNA candidates were run in 15 RIS patients, and their relative abundances were analyzed.Results:
A specific profile of deregulated circulating miRNAs (miR-144-3p, miR-448 and miR-653-3p in cerebrospinal fluid and miR-142-3p, miR-338-3p, miR-363-3p, miR-374b-5p, miR-424-5p, miR-483-3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up.Conclusion:
Circulating miRNAs might be used as prognostic biomarkers for RIS patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Desmielinizantes
/
MicroRNA Circulante
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha