Cytotoxicity, <i>in silico</i> predictions and molecular studies for androstane heterocycle compounds revealed potential antitumor agent against lung cancer cells.

Tantawy, Mohamed A; Shaheen, Sameerah; Kattan, Shahad W; Alelwani, Walla; Barnawi, Ibrahim O; Elmgeed, Gamal A; Nafie, Mohamed S

Cytotoxicity, in silico predictions and molecular studies for androstane heterocycle compounds revealed potential antitumor agent against lung cancer cells.

Tantawy, Mohamed A; Shaheen, Sameerah; Kattan, Shahad W; Alelwani, Walla; Barnawi, Ibrahim O; Elmgeed, Gamal A; Nafie, Mohamed S.

Afiliação

Tantawy MA; Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt.
Shaheen S; Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt.
Kattan SW; Anatomy Department and Stem Cell Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Alelwani W; Medical Laboratory Department, College of Applied Medical Sciences, Taibah University, Yanbu, Saudi Arabia.
Barnawi IO; Biochemistry Department, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Elmgeed GA; Department of Biological Sciences, Faculty of Science, Taibah University, Al-Madinah Al Munawwarah, Saudi Arabia.
Nafie MS; Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt.

J Biomol Struct Dyn ; 40(10): 4352-4365, 2022 07.

Article em En | MEDLINE | ID: mdl-33300466

Assuntos

Antineoplásicos; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Androstanos/farmacologia; Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose; Linhagem Celular Tumoral; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Interleucina-6; Neoplasias Pulmonares/tratamento farmacológico; Simulação de Acoplamento Molecular; Tubulina (Proteína)/metabolismo

Palavras-chave

Androstane; IL6/JAK/STAT3; apoptosis; heterocycles; lung cancer; tubulin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Reino Unido

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