Potential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis.
Med Hypotheses
; 146: 110432, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33303308
ABSTRACT
Pyruvate dehydrogenase (PDH) deficiency is an inherited metabolic disorder caused by a defect in any subunit of the pyruvate dehydrogenase complex (PDHC), which has an essential role in glucose metabolism. The causes of disease progression in PDH deficiency are not fully understood yet. Based on repeated observations of a patient with PDH deficiency at our center, we hypothesized that stress-induced gluconeogenesis contributes to rapid exacerbation of the disease. This link has not been established previously.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Deficiência do Complexo de Piruvato Desidrogenase
Limite:
Humans
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
2021
Tipo de documento:
Article