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Developing the 134Ce and 134La pair as companion positron emission tomography diagnostic isotopes for 225Ac and 227Th radiotherapeutics.
Bailey, Tyler A; Mocko, Veronika; Shield, Katherine M; An, Dahlia D; Akin, Andrew C; Birnbaum, Eva R; Brugh, Mark; Cooley, Jason C; Engle, Jonathan W; Fassbender, Michael E; Gauny, Stacey S; Lakes, Andrew L; Nortier, Francois M; O'Brien, Ellen M; Thiemann, Sara L; White, Frankie D; Vermeulen, Christiaan; Kozimor, Stosh A; Abergel, Rebecca J.
Afiliação
  • Bailey TA; Department of Nuclear Engineering, University of California, Berkeley, CA, USA.
  • Mocko V; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Shield KM; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • An DD; Department of Nuclear Engineering, University of California, Berkeley, CA, USA.
  • Akin AC; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Birnbaum ER; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Brugh M; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Cooley JC; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Engle JW; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Fassbender ME; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Gauny SS; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
  • Lakes AL; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Nortier FM; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • O'Brien EM; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Thiemann SL; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • White FD; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Vermeulen C; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Kozimor SA; Los Alamos National Laboratory, Los Alamos, NM, USA.
  • Abergel RJ; Los Alamos National Laboratory, Los Alamos, NM, USA. etienne@lanl.gov.
Nat Chem ; 13(3): 284-289, 2021 03.
Article em En | MEDLINE | ID: mdl-33318671
ABSTRACT
Developing targeted α-therapies has the potential to transform how diseases are treated. In these interventions, targeting vectors are labelled with α-emitting radioisotopes that deliver destructive radiation discretely to diseased cells while simultaneously sparing the surrounding healthy tissue. Widespread implementation requires advances in non-invasive imaging technologies that rapidly assay therapeutics. Towards this end, positron emission tomography (PET) imaging has emerged as one of the most informative diagnostic techniques. Unfortunately, many promising α-emitting isotopes such as 225Ac and 227Th are incompatible with PET imaging. Here we overcame this obstacle by developing large-scale (Ci-scale) production and purification methods for 134Ce. Subsequent radiolabelling and in vivo PET imaging experiments in a small animal model demonstrated that 134Ce (and its 134La daughter) could be used as a PET imaging candidate for 225AcIII (with reduced 134CeIII) or 227ThIV (with oxidized 134CeIV). Evaluating these data alongside X-ray absorption spectroscopy results demonstrated how success relied on rigorously controlling the CeIII/CeIV redox couple.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cério / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Lantânio Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Nat Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cério / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Lantânio Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Nat Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos