Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice.
Cell Rep
; 33(11): 108507, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-33326790
ABSTRACT
The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Microglia
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Cell Rep
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos