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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
Guan, Junhong; Lu, Changzheng; Jin, Qihuang; Lu, Huiming; Chen, Xiang; Tian, Lei; Zhang, Yanbin; Ortega, Janice; Zhang, Junqiu; Siteni, Silvia; Chen, Mingyi; Gu, Liya; Shay, Jerry W; Davis, Anthony J; Chen, Zhijian J; Fu, Yang-Xin; Li, Guo-Min.
Afiliação
  • Guan J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Lu C; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jin Q; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Lu H; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chen X; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Tian L; Department of Cancer Biology, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Zhang Y; Department of Biochemistry & Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Ortega J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Zhang J; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Siteni S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chen M; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Gu L; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Shay JW; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Davis AJ; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chen ZJ; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Fu YX; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: yang-xin.fu@utsouthwestern.edu.
  • Li GM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: guo-min.li@utsouthwestern.edu.
Cancer Cell ; 39(1): 109-121.e5, 2021 01 11.
Article em En | MEDLINE | ID: mdl-33338427
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Aberrações Cromossômicas / Enzimas Reparadoras do DNA / Exodesoxirribonucleases / Proteína 1 Homóloga a MutL / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Aberrações Cromossômicas / Enzimas Reparadoras do DNA / Exodesoxirribonucleases / Proteína 1 Homóloga a MutL / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos