Your browser doesn't support javascript.
loading
The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.
Jiang, Mei; Fares, Aline F; Shepshelovich, Daniel; Yang, Ping; Christiani, David; Zhang, Jie; Shiraishi, Kouya; Ryan, Brid M; Chen, Chu; Schwartz, Ann G; Tardon, Adonina; Shete, Sanjay; Schabath, Matthew B; Teare, M Dawn; Le Marchand, Loic; Zhang, Zuo-Feng; Field, John K; Brenner, Hermann; Diao, Nancy; Xie, Juntao; Kohno, Takashi; Harris, Curtis C; Wenzlaff, Angela S; Fernandez-Tardon, Guillermo; Ye, Yuanqing; Taylor, Fiona; Wilkens, Lynne R; Davies, Michael; Liu, Yi; Barnett, Matt J; Goodman, Gary E; Morgenstern, Hal; Holleczek, Bernd; Thomas, Sera; Brown, M Catherine; Hung, Rayjean J; Xu, Wei; Liu, Geoffrey.
Afiliação
  • Jiang M; Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzh
  • Fares AF; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Hospital de Base, São José do Rio Preto, São Paulo, Brazil.
  • Shepshelovich D; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Yang P; Mayo Clinic, Rochester, MI, USA.
  • Christiani D; Environmental Health Department, Harvard TH Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
  • Zhang J; Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, USA; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Shiraishi K; Division of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
  • Ryan BM; Centre for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
  • Chen C; Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology and Department of Otolaryngology: Head and Neck Surgery, University of Washington, Seattle, WA, USA.
  • Schwartz AG; Barbara Ann Karmanos Cancer Institute, Wayne State University Detroit, MI, USA.
  • Tardon A; IUOPA, University of Oviedo and CIBERESP, Oviedo, Spain.
  • Shete S; University of Texas MD Anderson Cancer Center, Texas, USA.
  • Schabath MB; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
  • Teare MD; University of Sheffield, Sheffield, UK.
  • Le Marchand L; University of Hawaii Cancer Centre, Honolulu, HI, USA.
  • Zhang ZF; University of California Los Angeles School of Public Health, CA, USA.
  • Field JK; The Roy Castle Lung Cancer Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.
  • Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Res
  • Diao N; Environmental Health Department, Harvard TH Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
  • Xie J; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Kohno T; Division of Genome Biology, National Cancer Research Institute, Tokyo, Japan.
  • Harris CC; Centre for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
  • Wenzlaff AS; Barbara Ann Karmanos Cancer Institute, Wayne State University Detroit, MI, USA.
  • Fernandez-Tardon G; IUOPA, University of Oviedo and CIBERESP, Oviedo, Spain.
  • Ye Y; University of Texas MD Anderson Cancer Center, Texas, USA.
  • Taylor F; University of Sheffield, Sheffield, UK.
  • Wilkens LR; University of Hawaii Cancer Centre, Honolulu, HI, USA.
  • Davies M; The Roy Castle Lung Cancer Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.
  • Liu Y; Mayo Clinic, Rochester, MI, USA; PLA Hospital, Beijing, China.
  • Barnett MJ; Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Goodman GE; Swedish Cancer Institute, Seattle, WA, USA.
  • Morgenstern H; Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Holleczek B; Saarland Cancer Registry, Saarbrücken, Germany.
  • Thomas S; Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
  • Brown MC; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
  • Hung RJ; Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
  • Xu W; Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Electronic address: Wei.Xu@uhnresearch.ca.
  • Liu G; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Departments of Medical Biophysics, Pharmacology and Toxicity, and IMS,
Lung Cancer ; 152: 58-65, 2021 02.
Article em En | MEDLINE | ID: mdl-33352384
ABSTRACT

INTRODUCTION:

The relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous. We evaluated the impact of sex, smoking and race on the relationship between BMI and overall survival (OS) in non-small-cell-lung-cancer (NSCLC).

METHODS:

Data from 16 individual ILCCO studies were pooled to assess interactions between BMI and the following factors on OS self-reported race, smoking status and sex, using Cox models (adjusted hazard ratios; aHR) with interaction terms and adjusted penalized smoothing spline plots in stratified analyses.

RESULTS:

Among 20,937 NSCLC patients with BMI values, females = 47 %; never-smokers = 14 %; White-patients = 76 %. BMI showed differential survival according to race whereby compared to normal-BMI patients, being underweight was associated with poor survival among white patients (OS, aHR = 1.66) but not among black patients (aHR = 1.06; pinteraction = 0.02). Comparing overweight/obese to normal weight patients, Black NSCLC patients who were overweight/obese also had relatively better OS (pinteraction = 0.06) when compared to White-patients. BMI was least associated with survival in Asian-patients and never-smokers. The outcomes of female ever-smokers at the extremes of BMI were associated with worse outcomes in both the underweight (pinteraction<0.001) and obese categories (pinteraction = 0.004) relative to the normal-BMI category, when compared to male ever-smokers.

CONCLUSION:

Underweight and obese female ever-smokers were associated with worse outcomes in White-patients. These BMI associations were not observed in Asian-patients and never-smokers. Black-patients had more favorable outcomes in the extremes of BMI when compared to White-patients. Body composition in Black-patients, and NSCLC subtypes more commonly seen in Asian-patients and never-smokers, may account for differences in these BMI-OS relationships.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article