Highly Sensitive Detection of CA 125 Protein with the Use of an n-Type Nanowire Biosensor.
Biosensors (Basel)
; 10(12)2020 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-33353197
ABSTRACT
The detection of CA 125 protein in a solution using a silicon-on-insulator (SOI)-nanowire biosensor with n-type chip has been experimentally demonstrated. The surface of nanowires was modified by covalent immobilization of antibodies against CA 125 in order to provide the biospecificity of the target protein detection. We have demonstrated that the biosensor signal, which results from the biospecific interaction between CA 125 and the covalently immobilized antibodies, increases with the increase in the protein concentration. At that, the minimum concentration, at which the target protein was detectable with the SOI-nanowire biosensor, amounted to 1.5 × 10-16 M.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
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Antígeno Ca-125
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Nanofios
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Biosensors (Basel)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Federação Russa