The use of topical oral antibiotics in head and neck prophylaxis: is it justified?
Laryngoscope
; 98(1): 26-9, 1988 Jan.
Article
em En
| MEDLINE
| ID: mdl-3336257
ABSTRACT
Systemic antibiotic therapy is widely used for prophylaxis in major head and neck surgery, but the efficacy of topical oral antibiotic therapy has not been adequately investigated. A pilot, placebo-controlled, double-blind crossover study using six healthy adult male volunteers was performed to assess the influence of topical clindamycin on oral flora. Samples of saliva were cultured for aerobic and anaerobic bacteria immediately before, and at 1- and 4-hour intervals after, rinsing the mouth with a solution of either placebo or clindamycin. Quantitative analysis demonstrated significantly reduced levels of both aerobic and anaerobic bacteria after use of the topical antibiotic at both the 1- and 4-hour intervals. It is postulated that topical clindamycin, by reducing concentrations of oral flora, may also reduce the incidence of regional infection following major upper aerodigestive tract surgery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Medicação
/
Clindamicina
/
Cabeça
/
Boca
/
Pescoço
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Laryngoscope
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
1988
Tipo de documento:
Article