Image quality and safety of automated carbon dioxide digital subtraction angiography in femoropopliteal lesions: Results from a randomized single-center study.
Eur J Radiol
; 135: 109476, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33388532
ABSTRACT
PURPOSE:
To evaluate the image quality and the safety of automated carbon dioxide (CO2) digital subtraction angiography (DSA). MATERIALS ANDMETHODS:
Fifty patients receiving DSA for femoropopliteal peripheral arterial disease (PAD) were enrolled in this single-center prospective study. All patients received iodinated contrast media (ICM) and CO2 as a contrast agent in the same target lesion. As a primary endpoint, four raters independently evaluated the angiography images based on overall image quality, visibility of collaterals, and assessment of stenoses/occlusions. Inter-rater agreement was assessed using the intraclass correlation coefficient (ICC) and differences between the raters were evaluated using Friedmann's test. Secondary endpoints were procedure safety and patient pain assessment.RESULTS:
Inter-rater agreement between CO2-DSA and ICM-DSA images was fair to excellent for overall image quality (ICC 0.399-0.748), fair to excellent for the visibility of collaterals (ICC 0.513-0.691), and poor to excellent for the assessment of stenoses/occlusions (ICC -0.065-0.762). There were no significant differences between the raters. Two patients had a hematoma, one reported pain related to puncture, one became nauseous, and one vomited. No other adverse events were observed. Reported pain scores were significantly higher for CO2-DSA vs. ICM-DSA (1.25 vs. 0625; pâ¯<â¯0.028).CONCLUSION:
CO2-DSA using automated injection system in combination with proprietary post-processing software is safe and comparable diagnostic test compared to ICM-DSA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dióxido de Carbono
/
Doença Arterial Periférica
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Eur J Radiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha