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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.
Scharping, Nicole E; Rivadeneira, Dayana B; Menk, Ashley V; Vignali, Paolo D A; Ford, B Rhodes; Rittenhouse, Natalie L; Peralta, Ronal; Wang, Yiyang; Wang, Yupeng; DePeaux, Kristin; Poholek, Amanda C; Delgoffe, Greg M.
Afiliação
  • Scharping NE; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Rivadeneira DB; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Menk AV; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Vignali PDA; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Ford BR; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
  • Rittenhouse NL; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
  • Peralta R; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Wang Y; School of Medicine, Tsinghua University, Beijing, China.
  • Wang Y; School of Medicine, Tsinghua University, Beijing, China.
  • DePeaux K; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.
  • Poholek AC; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
  • Delgoffe GM; Tumor Microenvironment Center, Department of Immunology, UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA. gdelgoffe@pitt.edu.
Nat Immunol ; 22(2): 205-215, 2021 02.
Article em En | MEDLINE | ID: mdl-33398183
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Ativação Linfocitária / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Metabolismo Energético / Microambiente Tumoral / Mitocôndrias Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Ativação Linfocitária / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Metabolismo Energético / Microambiente Tumoral / Mitocôndrias Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos