Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes.

Liao, Jianning; Dong, Jipan; Xu, Jiaqing; Wang, Wei; Wu, Yongjun; Hou, Yuxia; Guo, Hongchao

Liao, Jianning; Dong, Jipan; Xu, Jiaqing; Wang, Wei; Wu, Yongjun; Hou, Yuxia; Guo, Hongchao.

Afiliação

Liao J; Department of Chemistry, China Agricultural University, Beijing 100193, China.
Dong J; Department of Chemistry, China Agricultural University, Beijing 100193, China.
Xu J; Department of Chemistry, China Agricultural University, Beijing 100193, China.
Wang W; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wu Y; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Hou Y; Department of Chemistry, China Agricultural University, Beijing 100193, China.
Guo H; Department of Chemistry, China Agricultural University, Beijing 100193, China.

J Org Chem ; 86(3): 2090-2099, 2021 02 05.

Article em En | MEDLINE | ID: mdl-33400875

RESUMO

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google