Subjective Sleep Quality in Amnestic Mild Cognitive Impairment Elderly and Its Possible Relationship With Plasma Amyloid-ß.

ABSTRACT

STUDY OBJECTIVES: To investigate the extent to which sleep quality associated with plasma Aß levels in amnestic mild cognitive impairment (aMCI) elderly. METHODS: A total of 172 cognitively normal (NC) elderly and 133 aMCI elderly were included in this study. For the evaluation of sleep quality, the Pittsburgh Sleep Quality Index (PSQI) was used. Levels of plasma Aß were determined by the sandwich enzyme-linked immunosorbent assay technique. Multivariable linear regression analysis was applied to evaluate associations between sleep quality and plasma Aß levels after adjusting potential confounders. RESULTS: Compared to NC subjects, participants with aMCI had a higher global PSQI score (8.72 ± 3.87 vs. 7.10 ± 3.07, p < 0.001). The global PSQI score was positively associated with plasma Aß42 level in the aMCI group (ß = 0.063, 95% CI 0.001-0.125, and p = 0.049) but not in the NC group (p > 0.05). Additionally, a higher global PSQI score was associated with a higher plasma Aß42/Aß40 ratio in both NC (ß = 0.010, 95% CI 0.003-0.016, and p = 0.003) and aMCI groups (ß = 0.012, 95% CI 0.005-0.018, and p < 0.001). The association between global PSQI score and plasma Aß42/Aß40 ratio was stronger in individuals with aMCI relative to the NC subjects (ß = 0.076 vs. 0.030, p for interaction = 0.023). CONCLUSION: Poor sleep quality was associated with plasma Aß42 and Aß42/Aß40 ratio, with a stronger effect among individuals with aMCI. A better understanding of the role of sleep in plasma Aß levels in aMCI patients could lead to effective sleep-based intervention against the risk of Alzheimer's disease.