Antibacterial Activity of Senkyunolide A Isolated from Cnidium Officinale Extract.
J Cosmet Sci
; 71(6): 377-383, 2020.
Article
em En
| MEDLINE
| ID: mdl-33413782
ABSTRACT
In this study, we investigated the antibacterial and anti-inflammatory properties of Cnidium officinale hexane (COH) extract and senkyunolide A (SA). The antibacterial activities were measured using the paper disk diffusion method and minimum inhibitory concentration (MIC) against Propionibacterium acnes and Malassezia furfur. COH extract showed antibacterial activity at a concentration of 50 mg ml-1. The MICs of COH and SA were determined using the broth microdilution method. COH was found to be active on all the bacteria tested (10 ≤ MIC ≤ 20 mg ml-1). SA showed antibacterial activity against P. acnes. The anti-inflammatory properties were determined using a pancreatic lipase inhibition activity method, lipoxygenase inhibition activity, and inhibition of nitric oxide production activity. COH and SA inhibited the production of nitric oxide by up to 50 µg ml-1 in a dose-dependent manner. COH and SA possess antibacterial and anti-inflammatory activities. They could be used as antibacterial ingredients in various industries.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Cnidium
/
Antibacterianos
Idioma:
En
Revista:
J Cosmet Sci
Assunto da revista:
QUIMICA CLINICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Coréia do Sul